Bioinformatics Senior Scientist

At Pharmacyclics, our every effort is directed to bringing new therapies to life: treatments that help people return to the lives they love as quickly and easily as possible. We believe there is nothing more powerful than giving back in this way. We believe there is nothing more valuable than turning hope into reality and allowing people to focus on the splendor in every day. This is what we call the magic of normal—and we want this for as many people as possible.

Develop, maintain, and refine bioinformatics workflows and analytical tools for preclinical and clinical biomarker data analysis. Practical knowledge of bioinformatics tools and resources, experience with next generation sequencing (NGS) data, various high-throughput omics analysis pipeline development, and strong background in genomics and molecular biology. As a member of our bioinformatics group working with other research scientists and clinicians in a highly collaborative and dynamic environment to support biomarker investigations and translational medicine.

* Working with standard bioinformatics tools, visualization packages, and omics databases/annotations resources. * Automating, refining and implementing the processing and analysis of large data sets (especially for high dimensional integrative omics analyses). * Developing and using bioinformatics pipelines to prepare and analyze data. * Designing, developing, and maintaining databases for scientific and commercial applications. * Analyzing and working with NGS data, ideally whole genome and exome sequence data. * Interpreting and translating data to biological knowledge * Presentation in internal group meetings or external scientific meetings.

* Demonstrated fluency in UNIX/Linux computing environment (10+ years) * Proficiency in C/C++, R programming, and a scripting language (10+ years) such as Perl or Python (Java programming is a plus). * Familiarity with SAS, JMP or JMP Genomics, OmicSoft ArraySuite are a plus. * Good working knowledge of current best practices in genetic variant discovery and validation methods. * Strong organizational, written, and communication skills. * Good analytical and problem solving abilities. * A proven publication record. * Experience in human genetics and cancer biology is highly preferred. * Enjoys working in a fast paced and highly collaborative dynamic environment with a diverse team to tackle complex problems. * Eager to learn and think outside the box. * Is disciplined and driven to deliver ongoing research results. * Has a positive attitude with a willingness to roll up their sleeves and do what it takes to get the job done. * Is highly organized and detail oriented. * Is a strong written and verbal communicator. * Has a hard work ethic with emphasis on execution. * hD in Bioinformatics, Computational Biology, Statistical Genetics/Genomics, Computer Science, Statistics/Biostatistics with strong molecular biology background, or related field with additional postdoctoral or industry experience preferred. * Knowledge and skills and experiences in bioinformatics support for translational research/medicine and biomarker data packages