Senior Scientist, Neurovascular Biology

At Pfizer, we apply science and our global resources to bring therapies to people that extend and significantly improve their lives. We strive to set the standard for quality, safety and value in the discovery, development and manufacture of health care products.

The Neurovascular Biology Lab within the Pfizer Neuroscience Research unit located in Cambridge, MA is working to identify and validate novel vascular-based targets and improve neurovascular function for the treatment of CNS diseases and injury.

* Identify and validate new targets and mechanisms to improve neurovascular functioning * Design and support in vivo mechanistic studies evaluating blood-brain barrier integrity and trafficking of immune cells into the CNS. * Advance technical capabilities to measure cerebral blood flow and neurovascular coupling * Contribute to exploratory and portfolio projects focused on understanding how neurovascular pathology contributes to changes in neuronal circuit function in the context of CNS disease. * Be a part of an interdisciplinary team of scientists in the Neuroscience and Pain Research Unit. * Publish high-impact, cutting edge research in top tier scientific journals. **Target Identification & Validation:** * Designs and implements experiments to achieve a deep mechanistic understanding of target biology. * Collaborate with key internal and external biomedical scientists to drive improved understanding of disease pathophysiology and target biology to deliver a highly competitive and innovative early-stage drug discovery portfolio. * Foster collaborative and productive interactions between Pfizer colleagues and academic biomedical researchers. **Deliver the Neuroscience Research Unit Portfolio:** * Deliver high-value data and validated targets into the portfolio, and progress projects through the Neuroscience pipeline. **Communication:** * Foster a culture of open collaboration, communication and transparency. * Mentor lab members to develop experimental and critical thinking skills. * Clearly communicate and articulate the vision and strategy to colleagues in the NRSU. * Regularly report on project progress to Lab Head, Department Head, members of the Neuroscience Research Unit leadership team, and to other partners and stakeholders across the organization.

* Ph.D. or M.D./Ph.D. * Record of high quality scientific research and publications in top tier journals. * 2+ years of postdoctoral research or industry experience preferred. * Deep insight and knowledge of neurovascular and blood brain barrier biology and CNS pathology. * Established track record of innovation and successful interdisciplinary interactions. * Demonstrated ability to implement emerging technologies and approaches.