Sr./Principal Research Associate/Engineer, Production Science & Technology

Moderna is a clinical stage pioneer of messenger RNA Therapeutics™, an entirely new in vivo drug technology that produces human proteins, antibodies and entirely novel protein constructs inside patient cells, which are in turn secreted or active intracellularly.

Moderna Therapeutics is seeking a Sr./Principal Research Associate/Engineer for a position based at their Cambridge, MA site.

* Assist in identification, development and optimization of mRNA synthesis and purification methodologies * Optimize unit operations to improve robustness, cycle time, throughput, and cost while maintaining product quality * Develop and evaluate scale-up and scale-down process models * Support implementation of novel process solutions into the mRNA production platform * Provide technical support to members of production group. * Identify opportunities for improvement and efficiency needed to meet critical corporate objectives, encompassing the areas of process, equipment, procedures, automation, and work flows in the Production Facility. * Support cross-functional projects with Process Innovation/ CMC PD, Production, Automation, and Analytical Development, and Chemistry.

* BS in Chemical Engineering, Chemistry, Biochemical Engineering, Biochemistry, Molecular Biology, or closely related field * 2-7 years of relevant industry experience * Experience with preparative chromatographic purification. * Experience working in a process development/ R&D/ high-throughput screening environment * BS with 7+ years or MS with 2+ years of experience in Chemical Engineering, Chemistry, Biochemical Engineering, Biochemistry, Molecular Biology, or closely related field. * Relevant experience working with biomacromolecules (RNA, DNA, proteins, mAbs) * Demonstrated proficiency with chromatographic separations as well as additional macromolecule purification and filtration techniques * Experience in process scale-up /scale-down modeling * Experience optimizing chemical reactions/enzymatic reactions. * Knowledge of nucleic acid chemistry/biochemistry is a plus * Proficiency with analytical instruments including capillary electrophoresis, HPLC/UPLC, Mass Spectrometry * Experience using bio-conjugation techniques * Familiarity with automation including liquid handlers * Familiarity with lean manufacturing concepts and implementation * ollaboration * Communication * Creative Problem Solving * Exemplary Work Ethic, Driven by the Mission * Risk Taking / Accountability * Desire for Impact