Senior Bioprocess Engineer, Protein Production

Genocea finds targets of T cell responses to discover and develop life-changing medicines. We’ve created a pipeline of novel vaccine and immunotherapy programs that stimulate the T cell arm of the immune system, which is increasingly recognized as critical to generating protective immune responses against a wide array of diseases.

We are seeking an experienced Bioprocess Engineer to join our Protein Production team to contribute to the development of protein-based vaccines for the prevention and treatment of infectious diseases with significant impacts on human health.

* Provide support for tech transfer, process characterization, manufacturing and process validation campaigns occurring at CMOs (on-site as needed) * Develop and maintain strong working relationships with CMO technical personnel * Carry out data trending and statistical analyses of these campaigns * Facilitate risk assessments, including developing mitigation strategies and * Liaise with CMOs to finalize risk assessments, control strategies, process characterization/validation protocols and reports * Assist manufacturing teams to achieve cost effectiveness and optimal product quality * Employ data analysis methods and techniques, including multivariate methods * Help develop technical strategies and scale down studies to provide a science-based approach for the resolution of deviations, investigations and process issues

* Experience with cGMP activities and environment * Solid understanding of DSP development and optimization, including harvest recovery, chromatography (Akta/Avant) and UF-DF * Demonstrated expertise in DOE, QbD and Design Space concepts * Knowledge of scale-up and scale-down models * Must be flexible and able to work well within a fast-paced, dynamic and team-oriented start-up environment * Must possess solid organizational, interpersonal and problem solving skills * B.S. (8-plus years industrial experience) or M.S. (6-plus years industrial experience) degree in Chemical/Biochemical Engineering * Relevant work experience in vaccines manufacturing would be a plus