Research Scientist II - Pharmacology

Geisinger Health System

(Danville, Pennsylvania)
Full Time
Job Posting Details
About Geisinger Health System
Expertise, Innovation, Commitment Geisinger Health System is an integrated health services organization widely recognized for its innovative use of the electronic health record and the development of innovative care delivery models such as ProvenHealth Navigator® and ProvenCare®.
Summary
We are seeking a skilled, creative, and highly motivated scientist in the GPCR field with hands-on experience in functional characterization of these receptors in heterologous and native cells. This individual will work as part of a team with cross disciplinary expertise (i.e., next generation sequencing, bioinformatics, genotype-phenotype association analyses, and functional screening) to identify new biological functions and disease contributions for members of the G-protein coupled receptor family. The GPCRs are one of most successful class of drug targets for the pharmaceutical industry. A small number of these receptors represent the targets for nearly 50% of the drugs on the market. This leaves a large number of receptors that have no known ligands, biological functions, or disease associations (i.e., orphan receptors). This project leverages our access to whole exome sequence data and clinical data from >50,000 patient volunteers to identify orphan receptor gene variants that are associated with particular clinical phenotypes (i.e., disease diagnoses, laboratory values, medications). To further assess their mechanistic contributions to these clinical phenotypes, we will use this list of clinically impactful orphan receptor gene variants to create human disease models by generating iPS cells carrying these variants, implementing high throughput functional screens, and using an established drug screening platform to identify potential ligands capable of modulating the risk or progression of these diseases.
Responsibilities
Commensurate the higher rank of this position, the candidate will be responsible for designing and carrying out her/his experiments, communicating the data in the appropriate format, and contributing to the overall operational functioning of the team. By bridging the basic-clinical divide, the candidate will have ample opportunity to author highly impactful publications reflective of her/his contributions and to be competitive for national research grants. This position is available immediately.
Ideal Candidate
The ideal candidate is expected to have a MD or PhD degree in the field of GPCR pharmacology, along with a proven track record of publications. She/He will have a solid background in establishing binding and functional GPCR assays. Previous experience in high content imaging to measure GPCR activity/localization and experience in setting up FRET or BRET assays to detect protein-protein interactions are highly desirable. Additional experience in the latest genome editing technologies is also advantageous. The successful candidate is expected to be highly collegial and to possess excellent communication skills – both oral and written.

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