Scientist II, Toxicology

Biogen (NASDAQ: BIIB) is a biotechnology leader that discovers, develops and delivers innovative therapies to improve the lives of patients with neurodegenerative diseases, hematologic conditions and autoimmune diseases. Patients worldwide benefit every day from our medicines for multiple sclerosis (MS) and hemophilia.

This is a critical position to provide timely and insightful analysis of toxicology information relevant to decisions around target pathway selection, candidate prioritization and development transitions in support of Biogen’s Discovery stage portfolio. Close collaboration with discovery teams working on small and large molecules. Opportunities exist to expand responsibilities to include support for development programs.

* Drawing on previous training in toxicology and research, this dynamic individual will be a key participant in discovery program teams. The qualified individual will provide toxicological context to discovery stage decisions through understanding of the target pathway, identifying potential safety concerns based on literature review, and design an appropriate discovery toxicology screening and testing paradigm. * With a knowledge-base of biologic drugs and protein chemistry, the position will provide guidance on the design of appropriate early stage studies, species selection, inclusion of safety biomarkers, and dose selection of biologic drug candidates. * Provide guidance / lead assessment of innovative technologies and databases in the field of toxicology, evaluate new in vitro and in vivo screening assays, and provide recommendations to advance Biogen’s toxicology screening strategy as appropriate. * Serve as liaison and advisor to discovery teams on lead identification strategy, summarize toxicology profile and provide recommendation of advancement of molecules to enable earliest possible go/no go decision. * Collaborate effectively with other scientists, including medicinal chemists, protein chemists, pathologists, study managers, pharmacokineticists, and pharmacologists, to design, execute and interpret results from in vitro and in vivo toxicology studies at the discovery stage in our fully outsourced business model. * Deliver impactful oral presentations on strategy, study design, and data analysis to Preclinical Safety, discovery program teams, and senior management forums. * Act as a preclinical safety subteam lead on assigned programs. * Collaborate with regulatory toxicologists on development programs during transition of molecules from discovery to development. * May serve as a subject matter expert (SME) within their field of specialization to provide input on other programs and studies in discovery and development. * Participate in Biogen subcommittees for process improvement / modernization, as required. * Maintain contact with external expertise in toxicology. * May represent Biogen on external scientific committees and industry working groups in the area of drug discovery toxicology.

* Toxicology board certification preferred. * Minimum of 5 years toxicology experience including the conduct of various aspects of preclinical toxicological evaluations, particularly small molecule drugs. Up to 2 years postdoctoral research experience in a relevant field would be considered contributory to the duration of experience requirement. * Working knowledge and experience in the early development of small molecules and biologic drug candidates. * Knowledge of drug development principles with emphasis on early stage discovery. * Demonstrated experience and expertise with both in vitro and in vivo toxicology. * Previous toxicology laboratory experience is a plus. * Proven organization and time management skills including ability to manage outsourced studies. * Communication skills: must possess speaking and writing skills that will enable him/her to provide clear ideas and rationale for study designs and analyses. Must also be capable of engaging in scientific dialog among large groups of scientists, senior management, and external experts. **Education** * Ph.D. or equivalent in Toxicology, Pharmacology, or closely related field